2024 Lamp2b

Lamp2b

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TīmeklisDownload scientific diagram Targeting peptide expressed with Lamp2b is expressed on the external surface of exosomes. (a) Schematic representation of production, harvest and re-administration of ... Tīmeklis2024. gada 18. marts · LAMP2B is the predominant isoform expressed in cardiomyocytes. This study evaluates the efficacy of human LAMP2B gene transfer …

外泌体靶向药物递送体系——骨关节炎的无细胞疗法- X-MOL资讯

Tīmeklis2024. gada 24. dec. · Here, we demonstrate that LAMP-2B promotes autophagosome–lysosome fusion in cardiomyocytes (CMs), independently of STX17. … TīmeklisPlasmid pCDNAHygro(+)LAMP2B from Dr. Janice Blum's lab contains the insert Lysosome-associated membrane protein 2b and is published in Immunity. 2005 May;22(5):571-81. This plasmid is available through Addgene. Image: Illustrated plasmid map in PNG format. GenBank File: Plasmid sequence and annotations. Use text … bulk supply essential oils

Delivery of siRNA to the mouse brain by systemic injection of ... - Nature

Tīmeklis2024. gada 23. maijs · The expression of CTP-Lamp2b peptide on exosomes was stabilized by attaching glycosylation sequences. Exosomes expressing only Lamp2b … Tīmeklis2024. gada 6. sept. · As a proof-of-principle study, RNA-binding protein HuR was fused to the C-terminus of Lamp2b, a membrane protein localized in both exosome and lysosome. The fusion protein was able to be incorporated into the exosomes. Moreover, exosomes engineered with Lamp2b-HuR successfully decreased the abundance of … TīmeklisPlasmid pcDNA Flag Lamp2b-HA from Dr. Joshua Leonard's lab contains the insert Lamp2b and is published in J Biol Chem. 2015 Mar 27;290(13):8166-72. doi: … bulk tissue

Targeting peptide expressed with Lamp2b is expressed on the …

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Tīmeklis2024. gada 6. sept. · Lamp2b alone or fusion protein was cloned into pcDNA 3.1(-) similarly as described before . For Lamp2b-empty vector construction, the Lamp2b CDS was amplified using corresponding primers, followed by direct clone into pcDNA 3.1(-). For HuR-Lamp2b vector construction, Xho1 and BspE1 cloning sites were … Tīmeklis一种基于Lamp2b的融合蛋白可用于在表面显示狂犬病病毒糖蛋白（RVG），当这些胞外体被系统地给予时，表面展示的RVG导致这些胞外体在小鼠的神经元和大脑中积聚 … bulk tall tin containersTīmeklis2024. gada 1. febr. · Plasmid CAP-lamp2b includes a glycosylation sequence (GNSTM), a E7 sequence (EPLQLKM) and glycine-serine spacers at the N-terminus of lamp2b … bulk tie dye kits

"Tīmeklis2011. gada 20. marts · Lamp2b was cloned with cDNA from C2C12 cells and XhoI and BspEI restriction sites were inserted after the signal peptide sequence together with glycine linkers using primers listed in ... " - Lamp2b

Lamp2b

Fusion protein engineered exosomes for targeted degradation of ... - PubMed

Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. The protein encoded by this gene is a member of a family of membrane glycoproteins. This … Skatīt vairāk The gene for LAMP2 has 9 coding exons and 2 alternate last exons, 9a and 9b. When the last exon is spliced with the alternative exon, it is a variant called LAMP2b, which varies in the last 11 amino acids of its C … Skatīt vairāk Lysosomes are cell organelles found in most animal cells. Their main functions center around breaking down materials and debris in the cell. Some of this is done via acid … Skatīt vairāk • CA77.1 • QX39 Skatīt vairāk • LAMP2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • PDBe-KB provides an … Skatīt vairāk LAMP2 has been specifically implicated in tumor cell metastasis. Both LAMP1 and LAMP2 have been found expressed on the surface of … Skatīt vairāk • Cluster of differentiation Skatīt vairāk • Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2)". Journal of Biological Regulators and … Skatīt vairāk Tīmeklis1.一种用于肿瘤放疗增敏的工程化外泌体，其特征在于，所述用于肿瘤放疗增敏的工程化外泌体外部修饰肿瘤靶向肽，内部包裹小干扰RNA核酸药物。 2.根据权利要求1所述的用于肿瘤放疗增敏的工程化外泌体，其特征在于，所述核酸药物是长度为15‑30个核苷酸。 3.根据权利要求2所述的用于肿瘤放疗增 ...

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Tīmeklis研究mirna的靶点mrna，构建过表达质粒，是否需要考虑3‘utr区，还是只过表达cds区就行了？. rt，因为mirna和mrna的3’utr区结合，过表达是仅过表达cds区是不是没有效果？是不是要包含3‘utr区？. 丁香园-核酸基因技术-2024-05-03 09:48:59 Tīmeklis2024. gada 15. nov. · 细胞外小囊泡（ sEVs RVG ）的脑部神经特异性靶向是通过将 s EVs膜蛋白lamp2b 和神经靶向性的狂犬病毒糖蛋白衍生肽（RVG）融合递呈在细胞外囊泡上，在细胞及动物水平验证了 sEVs RVG-siRNA 的抗病毒能力. 图3： sEVs RVG-siRNA 装载siRNA条件的优化及其在细胞水平 ...

TīmeklisRP-A501 is an investigational gene therapy product being developed for Danon Disease and the first potential gene therapy for monogenic heart failure. It consists of a recombinant adeno-associated serotype 9 (AAV9) capsid containing a functional version of the human LAMP2B transgene (AAV9.LAMP2B). RP-A501 is currently being … Tīmeklis2024. gada 1. febr. · The pEGFP-C1-RVG-Lamp2b expressing vector was kindly provided by Prof. Matthew J A Wood’ lab from University of Oxford [70]. DNA sequence encoding the glycosylation sequon (GNSTM), E7 Peptide [55] and a glycine-serine spacer were synthesized and subcloned to replace the RVG fragment by XhoI/BspeI …

TīmeklisPlasmid pcDNA Flag Lamp2b-HA from Dr. Joshua Leonard's lab contains the insert Lamp2b and is published in J Biol Chem. 2015 Mar 27;290(13):8166-72. doi: 10.1074/jbc.M114.621383. Epub 2015 Feb 5. This plasmid is … Tīmeklis2024. gada 3. apr. · 公开资料显示，盐酸环丙沙星氟轻松滴耳液是一款治疗耳道炎的产品，已在美国、加拿大、欧盟、中国香港等多个国家和地区获得批准上市。 2月9日，药监局官网显示，辉瑞枸橼酸托法替布缓释片的新适应症获批上市。

Tīmeklis利用携带软骨细胞的亲合肽（CAP）融合表达展示于外泌体膜蛋白（lamp2b）上表面作为靶向的基因工程化外泌体可实现靶向软骨细胞（图1）。与无靶向的天然外泌体相比，关节内注射的CAP外泌体在能长时间保留在关节腔中，减少体内扩散。

TīmeklisPlays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the … bulk toilet paperTīmeklis2015. gada 3. marts · The Lamp2b fusion proteins were expressed at similar levels in cells, as indicated by the HA Western blot. However, the FLAG peptide on FLAG-Lamp2b-HA could not be detected, although the C-terminal FLAG peptide of Lamp2b-HA-FLAG was detected (Fig. 1 E). The same pattern was observed in exosomes … bulk topsoil kansas cityTīmeklisLAC2B is a leading Global E-Commerce Distributor of Cosmetics and Health products, with door to door delivery and a transit time of 24 hours / 96 hours directly to … bulk toilet rolls pallet bulk tissue paperTīmeklis2024. gada 22. apr. · Constructing Lamp2b–iRGD: The RVG fragments at both ends of the Lamp2b-RVG plasmid (i.e., enzyme digestion sites BspEI and XhoI) were replaced with iRGD peptides, single-stranded sequences synthesized through annealing of the restriction sites. Then, the sticky ends were, respectively, annealed with a forward … bulk toilet rolls ukTīmeklis2024. gada 4. aug. · For example, lysosome-associated membrane protein 2b (Lamp2b) is an exosomal surface protein with an exosomal signal peptide. Fusion of a protein of interest to Lamp2b is very common for displaying the protein on the surface of exosomes as a targeting moiety, ligand, or receptor. A Lamp2b-based fusion … bulk trolli lolliesTīmeklis2024. gada 15. nov. · 细胞外小囊泡（ sEVs RVG ）的脑部神经特异性靶向是通过将 s EVs膜蛋白lamp2b 和神经靶向性的狂犬病毒糖蛋白衍生肽（RVG）融合递呈在 … bulkaiser