Webb20 feb. 2007 · The pivotal role of His524 in maintaining the protein structure in the biologically active agonist conformation is elucidated. With His524 modeled as the … WebbThe bioactivities of the natural steroidal estrogen 17 beta-estradiol (E-2), the synthetic estrogen diethylstilbestrol (DES), and the phytoestrogen genistein (GEN) are intimately …
H-bonding occupancies of tested compounds with His524 (black …
WebbNM_020631.6(PLEKHG5):c.1569C>T (p.His523_His524=) AND multiple conditions Clinical significance: Likely benign (Last evaluated: Jul 7, 2024) Review status: 1 star out of … Webb4 mars 2024 · The glutamate residue of IER, which is coordinated to Zn 2+, makes a hydrogen bond with His524 via its backbone oxygen and also interacts with Glu396 and … kwesi adams
NM_020631.6(PLEKHG5):c.1569C>T (p.His523_His524=) AND …
Webb1 sep. 2024 · Visual inspection of the long-timescale (microsecond) simulation for the WT-E2 system revealed a ligand-mediated hydrogen-bonding network initiated by interaction of the D-ring hydroxyl of the E2 ligand with His524:Nδ. Because of all other systems lacked a bound ligand, only the subsequent interactions of the network were characterized. The ... Webb24 jan. 2024 · Bonding analysis suggested that previously reported important residue His524 lost bonding upon mutations. Other parameters such as PCA (principal component analysis), DCCM (dynamics cross-correlation), and FEL (free energy landscape) verified that the shortlisted mutations affect the H12 helix, which opens up the co-activator … Webb21 juli 2006 · The ab initio fragment molecular orbital calculations were performed for molecular interactions of the whole estrogen receptor (ER) ligand-binding domain with a natural ligand, 17β-estradiol (EST). The interaction energies of the ligand at the residue level were calculated using HF and MP2 methods with several basis sets. The charge … jazzy\\u0027s nails