WebNot for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. TARGET. ... (50 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with CTGF antibody (GTX124232) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary … WebFG-3019 is a fully human monoclonal antibody specific for CTGF. Pre-clinical studies suggest that FG-3019 penetrates into tissues to reduce effective tissue levels of CTGF resulting in reduction of pro-fibrotic factors, enabling a rebalancing of ECM secretion and processing, and a return toward tissue homeostasis.
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WebJun 6, 2012 · A monoclonal antibody to CTGF that is currently in clinical development (FG-3019) has demonstrated the ability to reverse vascular stiffening and improve cardiac function in a rat model of diabetic complications. FG-3019 has also exhibited activity in a murine radiation-induced pulmonary fibrosis model. WebJul 14, 2024 · FG-3019, an anti-CTGF monoclonal antibody, was used to inhibit CTGF. ... FG-3019 anti-connective tissue growth factor monoclonal antibody: results of an open-label clinical trial in idiopathic ... flight kc to la
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WebJan 12, 2011 · San Francisco, CA - January 12, 2011. FibroGen, Inc. today announced initiation of an open-label phase 2 study to evaluate the safety, tolerability, and efficacy of FG-3019, a human monoclonal antibody against connective tissue growth factor (CTGF), in individuals with idiopathic pulmonary fibrosis (IPF), a chronic, progressive, fatal lung … WebJun 22, 2006 · FG-3019 is an investigational fully human monoclonal antibody against CTGF. In a phase 1 study of FG-3019 in patients with idiopathic pulmonary fibrosis, FG-3019 was found safe and well tolerated. Currently, FG-3019 is the subject of a phase 1b study in diabetic patients with incipient nephropathy. WebCTGF and human anti-human antibodies (HAHA) levels. Plasma was obtained for pharmacokinetic (PK) analyses pre- and post FG-3019 infusions. FG-3019 exposure and plasma CTGF at baseline were correlated with clinical progression and survival outcomes. Assessments of CTGF were limited to baseline values, since subsequent chemistry unco